The increased interconnection among local and global players induced by globalization, as well as the need for a complete application of the “subsidiary principle”, calls for a re-thinking of the “corporate social responsibility” concept. This new concept broadens the perspective of the single company interacting with its own stakeholders in relation to specific social and environmental impacts, to a network of organizations, with different aims and natures, collaborating on relevant sustainability issues. Starting from a definition of “Territorial Social Responsibility”, the multi-stakeholder approach will be presented as a key driver toward local sustainable development. An analytical framework, designed in order to identify the main aspects, indicators and practices characterizing the territorial social responsibility concept, will represent a first attempt to create a feasible instrument aimed at understanding how cooperative social responsible actors, operating in the same territory, could influence the path toward sustainable development.